反応 #1328417

反応方程式

sodium hypochlorite

2-allyl-6-chlorobenzaldehyde oxime

sodium acetate

→

8-Chloro-3a,4-dihydro-3H-indeno[1,2-c]isoxazole

溶媒

methylene chloride

反応条件

後処理

1. 1
   その他the organic phase was separated off
2. 2
   抽出the aqueous phase was extracted with methylene chloride
3. 3
   洗浄the combined organic phases were washed with saturated ammonium chloride solution
4. 4
   その他The organic phase was dried
5. 5
   その他the solvent was removed

実験手順

At room temperature, 37.0 ml of a sodium hypochlorite solution (12.5% of active chlorine) were added dropwise to a solution of 8.4 g (42.9 mmol) of 2-allyl-6-chlorobenzaldehyde oxime in 100 ml of methylene chloride, and a spatula tip of sodium acetate was added. The mixture was stirred at room temperature for 2 hours, the organic phase was separated off, the aqueous phase was extracted with methylene chloride and the combined organic phases were washed with saturated ammonium chloride solution. The organic phase was dried and the solvent was removed. This gave 7.0 g (94%) of 8-chloro-3a,4-dihydro-3H-indeno-[1,2-c]isoxazole in the form of a viscous oil.

出典