反応 #1328416

反応方程式

2-allyl-6-chlorobenzaldehyde

sodium bicarbonate

hydroxylamine hydrochloride

→

2-Allyl-6-chlorobenzaldehyde oxime

溶媒

methanol

water

反応条件

後処理

1. 1
   その他The methanol was subsequently removed under reduced pressure
2. 2
   workup.STIRRINGthe residue was stirred into 300 ml of water
3. 3
   抽出The aqueous phase was extracted with diethyl ether
4. 4
   洗浄the combined organic phases were washed with saturated ammonium chloride solution
5. 5
   その他dried
6. 6
   その他the solvent was removed

実験手順

5.58 g of sodium bicarbonate were added to a solution of 4.62 g of hydroxylamine hydrochloride in 50 ml of water, and the mixture was cooled to 0° C. A solution of 9.7 g (44.32 mmol) of 2-allyl-6-chlorobenzaldehyde in 50 ml of methanol was then added dropwise, and the mixture was stirred at room temperature overnight. The methanol was subsequently removed under reduced pressure and the residue was stirred into 300 ml of water. The aqueous phase was extracted with diethyl ether and the combined organic phases were washed with saturated ammonium chloride solution and dried, and the solvent was removed. This gave 8.7 g (quantitative) of 2-allyl-6-chlorobenzaldehyde oxime in the form of a viscous oil.

出典