反応 #1328414

反応方程式

(R)-7-Diethylaminocarbonylmethyloxy-3-(2-phthalimidopropyl)indole

hydrazine monohydrate

→

title compound

収率 96.0%

(R)-7-diethylaminocarbonylmethyloxy-3-(2-aminopropyl)indole

収率 96.0%

溶媒

ethanol

反応条件

後処理

1. 1
   温度The suspension was heated
2. 2
   温度After cooling down
3. 3
   ろ過were filtered off
4. 4
   濃縮the filtrate was concentrated under reduced pressure
5. 5
   workup.ADDITIONEthyl acetate and a sodium hydroxide aqueous solution were added to the residue
6. 6
   洗浄the organic layer was further washed with a sodium hydroxide aqueous solution
7. 7
   その他dried
8. 8
   その他The solution was evaporated under reduced pressure
9. 9
   その他The resulting residue was slowly crystallized
10. 10
    その他dried under reduced pressure

実験手順

(R)-7-Diethylaminocarbonylmethyloxy-3-(2-phthalimidopropyl)indole 10.27 g was suspended in 100 ml of ethanol, and 2.5 ml of hydrazine monohydrate was added thereto. The suspension was heated to reflux in an oil bath of 85° C. For 3 hours. After cooling down, the resulting deposited insoluble materials were filtered off, and the filtrate was concentrated under reduced pressure. Ethyl acetate and a sodium hydroxide aqueous solution were added to the residue and distributed in liquid-liquid, and the organic layer was further washed with a sodium hydroxide aqueous solution and dried. The solution was evaporated under reduced pressure. The resulting residue was slowly crystallized, and dried under reduced pressure, whereby 6.90 g of the title compound was obtained in the form of a pale brownish white substance.

出典