反応 #1328413

反応方程式

N,N-diethylchloroacetamide

water

(R)-7-hydroxy-3-(2-phthalimidopropyl)indole

potassium carbonate

→

title compound

(R)-7-diethylaminocarbonylmethoxy-3-(2-phthalimidopropyl)indole

溶媒

acetone

反応条件

後処理

1. 1
   温度the solution was heated
2. 2
   workup.ADDITIONwas added
3. 3
   ろ過a deposited crystal was collected by filtration
4. 4
   洗浄washed with water

実験手順

A residue 10.27 g containing (R)-7-hydroxy-3-(2-phthalimidopropyl)indole was dissolved in 200 ml of acetone, and 8.00 g of potassium carbonate was added thereto. After addition of N,N-diethylchloroacetamide 15.5 ml, the solution was heated to reflux in an oil bath of 80° C. For 3 hours. After cooling down 200 ml of water was added, and a deposited crystal was collected by filtration and washed with water, whereby 9.56 g of the title compound was obtained in the form of a pale yellowish white substance.

出典