反応 #1328396

反応方程式

ethyl trifluoroacetate

4-methylaminobutanol

→

product

収率 96.0%

4-(N-Methyl-trifluoroacetamido)-1-butanol

収率 96.0%

溶媒

methanol

反応条件

後処理

1. 1
   workup.ADDITIONTo a 250 mL round bottom flask, charged with 10.0 g (96.9 mmol)
2. 2
   濃縮concentrated

実験手順

To a 250 mL round bottom flask, charged with 10.0 g (96.9 mmol) of is the amine, 4-methylaminobutanol, in 100 mL of dry methanol, was added 17.5 mL (147 mmol) of ethyl trifluoroacetate. The mixture was stirred at room temperature for 24 hours and then concentrated to afford 18.55 g of the product as a near colorless oil (96%): 1H-NMR (200 MHz, D2O); 3.63 and 3.50 (2t's, 4H), 3.20 and 3.05 (d and s, 3H), and 1.82–1.47 (m, 4H) ppm.

出典