反応 #1328394

反応方程式

2-aminoethanol

benzyl chloroformate

→

title compound

収率 66.0%

N-CBZ-2-aminoethanol

収率 66.0%

溶媒

CH2Cl2

CH2Cl2

反応条件

後処理

1. 1
   workup.ADDITIONAfter complete addition
2. 2
   その他purified by flash column chromatography on silica gel

実験手順

To 0° C. cold of CH2Cl2 solution (300 mL) of 2-aminoethanol (10.8 g, 0.177 mole) and TEA (26.8 g; 0.265 mole) was added slowly a CH2Cl2 solution (50 mL) of benzyl chloroformate (33.2 g, 0.194 mole). After complete addition, the resulting solution was gradually warmed to room temperature and stirring was continued at room temperature overnight. The reaction was worked up and purified by flash column chromatography on silica gel, affording 22.8 g in 66% yield of title compound. 1H NMR (CDCl3): δ 7.34-7.40 (m, 5H), 5.20-5.32 (m, 1H), 5.14 (s, 2H), 3.74 (q, 2H), 3.37 (q, 2H), 2.38 (bs, 1H).

出典