反応 #1284258

反応方程式

isopropanol

BOC-Arg

HCl

MeOH

→

H-Arg

収率 74.3%

溶媒

HCl AcOH

反応条件

後処理

1. 1
   その他The solution was reacted at room temperature for an hour
2. 2
   workup.ADDITIONwas added to the reaction mixture
3. 3
   その他precipitation again in AcOEt
4. 4
   ろ過The precipitated crystals were taken by filtration
5. 5
   その他dried

実験手順

BOC-Arg-CHA.HCl, 243.7 g (0.55 mole), was dissolved in 1093 ml of 2N HCl/AcOH and a small amount of MeOH. The solution was reacted at room temperature for an hour. After completion of the reaction, 1093 ml of isopropanol was added to the reaction mixture to cause precipitation again in AcOEt. The precipitated crystals were taken by filtration and dried to give 156.2 g (74.3%) of H-Arg-CHA.2HCl.

出典