反応 #1284180

反応方程式

4-methylpiperazine

methyl 11-methylene-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate

trifluoroacetic acid

→

Methyl 11-[2-(4-methylpiperazino)ethylidene]-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate

溶媒

tetrachloroethane

tetrachloroethane

反応条件

後処理

1. 1
   その他a solution obtained
2. 2
   workup.ADDITIONis dropwise added
3. 3
   workup.STIRRINGthe mixture is stirred at 90° C. for 3 hours

実験手順

In this example, 1.5 ml of 4-methylpiperazine and 0.37 g of p-formaldehyde are dissolved in 100 ml of tetrachloroethane. To the solution is dropwise added 5 ml of trifluoroacetic acid. After stirring the mixture at 60° C. for 2 hours, a solution obtained by dissolving 1.8 g of methyl 11-methylene-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate in 30 ml of tetrachloroethane is dropwise added thereto and the mixture is stirred at 90° C. for 3 hours.

出典