反応 #1284035

反応方程式

3-(2,3-epoxypropoxy)-5-phenylisoxazole

morpholine

→

3-(2-Hydroxy-3-morpholinopropoxy)-5-phenylisoxazole

収率 89.2%

title compound

収率 89.2%

溶媒

ethanol

反応条件

後処理

1. 1
   温度the mixture was refluxed
2. 2
   温度by heating for 5 hours
3. 3
   濃縮followed by concentration under reduced pressure
4. 4
   その他The resulting solid was recrystallized from ethyl acetate

実験手順

To a solution of 40.0 g of 3-(2,3-epoxypropoxy)-5-phenylisoxazole dissolved in ethanol (400 ml) was added 17.6 g of morpholine and the mixture was refluxed by heating for 5 hours, followed by concentration under reduced pressure. The resulting solid was recrystallized from ethyl acetate to afford 50.0 g of the title compound with melting point 123°-124° C. as colorless columns.

出典