反応 #1283844

反応方程式

p-chlorobenzoyl chloride

triethylamine

3-oxocyclohexanecarboxylate

morpholine

p-toluenesulfonic acid

→

ethyl 2-(4-chlorobenzoyl)-1-morpholino-4-cyclohexenecarboxylate

溶媒

toluene

toluene

toluene

反応条件

後処理

1. 1
   温度under reflux for 6 hours in a Dean-Stark apparatus
2. 2
   温度heated at 60° C. for 3 hours
3. 3
   温度The solution was cooled
4. 4
   ろ過filtered
5. 5
   その他The filtrate was evaporated

実験手順

A solution of 3.12 g (0.02 mol) of 3-oxocyclohexanecarboxylate, 1.91 g (0.022 mol) of morpholine and 0.01 g of p-toluenesulfonic acid in 300 ml of toluene was heated under reflux for 6 hours in a Dean-Stark apparatus. The solution was cooled to 0° C. and there were added 2.02 g (0.02 mol) of triethylamine in 5 ml of toluene followed by 3.83 g (0.02 mol) of p-chlorobenzoyl chloride in 30 ml of toluene over a period of 0.5 hour. The mixture was stirred at 20° C. for 3 hours and then heated at 60° C. for 3 hours. The solution was cooled and filtered. The filtrate was evaporated to give ethyl 2-(4-chlorobenzoyl)-1-morpholino-4-cyclohexenecarboxylate as a gum which was dissolved in 10 ml of ethanol and 5 ml of pyridine and treated with 1.4 g (0.02 mol) of hydroxylamine hydrochloride. The mixture was then heated under reflux for 2 hours. The solvents were removed by evaporation, 2N hydrochloric acid was added to the residue and the product was extracted with diethyl ether. Evaporation of the ethereal extract gave 1 g of methyl 3-(4-chlorophenyl)-4,5,6,7-tetrahydro-2,1-benzisoxazole-6-carboxylate of melting point 141°-143° C. (from ethyl acetate/hexane).

出典