反応 #1282168

反応方程式

HCl

HCl AcOH

MeOH

BOC-Arg

→

H-Arg

収率 163.0%

溶媒

isopropyl alcohol

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他the product was re-precipitated in AcOEt
3. 3
   ろ過The deposited crystalline product was collected by filtration
4. 4
   その他dried

実験手順

Into a mixture consisting of 1,093 ml of 2N HCl/AcOH and a small quantity of MeOH was dissolved 243.7 g (0.55 mole) of BOC-Arg-CHA.HCl, and the resulting solution was reacted at room temperature for one hour. After the reaction, 1,093 ml of isopropyl alcohol was added, and the product was re-precipitated in AcOEt. The deposited crystalline product was collected by filtration and dried to obtain 156.2 g (74.3%) of H-Arg-CHA.2HCl.

出典