反応 #1279330

反応方程式

5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride

4-(1-hydroxyethyl)aniline

→

title compound

5-((3,5-dichloropyridin-4-yl)thio)-N-(4-(1-hydroxyethyl)phenyl)-4-nitrothiophene-2-carboxamide

反応条件

後処理

1. 1
   その他Prepared

実験手順

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (120 mg, 0.33 mmol) and 4-(1-hydroxyethyl)aniline (53 mg, 0.39 mmol). The title compound was obtained as a solid (50 mg, 33% yield). 1H NMR (400 MHz, d6-DMSO) δ: 10.50 (1H, s), 9.00 (2H, s), 8.72 (1H, m), 7.56 (2H, dd), 7.32 (2H, dd), 5.10 (1H, m), 4.68 (1H, m), 1.31 (3H, s). MS m/z: 468.10, 470.10 [M+H]+.

出典