反応 #1273179

反応方程式

10

methyl 4-(3-tert-butoxycarbonylmethyl-6-methylimidazo[1,2-a]pyridin-2-yl)benzoate

trifluoroacetic acid

→

[2-(4-carboxymethylphenyl)-6-methylimidazo[1,2-a]pyridin-3-yl]acetic acid

収率 62.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   濃縮was concentrated to dryness
2. 2
   workup.ADDITIONPotassium carbonate (10%) solution (100 ml) was added
3. 3
   洗浄the solution washed with diethyl ether (2×50 ml)
4. 4
   ろ過The precipitate was filtered
5. 5
   洗浄washed with diethyl ether
6. 6
   その他recrystallized

実験手順

A solution of 10 (3.1 g, 8.15 mmol) in dichloromethane (50 ml) was added to trifluoroacetic acid (25 ml). Following stirring at room temperature for 2 h the solution was concentrated to dryness. Potassium carbonate (10%) solution (100 ml) was added and the solution washed with diethyl ether (2×50 ml) and acidified to pH 6 with HCl (6M). The precipitate was filtered, washed with diethyl ether and recrystallized to give [2-(4-carboxymethylphenyl)-6-methylimidazo[1,2-a]pyridin-3-yl]acetic acid 11 as a white solid (1.65 g, 62%).

出典