反応 #1270347

反応方程式

1-(2-fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid

TOTU

(S)-3-amino-3-o-tolyl-propionic acid

→

title compound

収率 28.0%

(S)-3-{[1-(2-Fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid

収率 28.0%

溶媒

DMF

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture stirred overnight at room temperature
2. 2
   その他The solvent was evaporated in vacuo

実験手順

0.45 mmol of 1-(2-fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid were dissolved in 5 ml of DMF, 0.54 mmol of TOTU and 1.125 mmol of NEM were added, and the mixture was stirred for 5 min at room temperature. Then 0.495 mmol of (S)-3-amino-3-o-tolyl-propionic acid were added and the mixture stirred overnight at room temperature. The solvent was evaporated in vacuo and the residue subjected to preparative HPLC to give the title compound in a yield of 28%.

出典