反応 #1269866

反応方程式

solution

4-(2-{[5-(2-Carboxy-ethylamino)-2-phenyl-thiazole-4-carbonyl]-amino}-acetyl)-piperazine-1-carboxylic acid butyl ester

H2SO4

EtOH

→

desired product

4-(2-{[5-(2-Ethoxycarbonyl-ethylamino)-2-phenyl-thiazole-4-carbonyl]-amino}-acetyl)-piperazine-1-carboxylic acid butyl ester

溶媒

H2O

反応条件

後処理

1. 1
   抽出extracted with EtOAc (2×)
2. 2
   乾燥layers were dried over Na2SO4
3. 3
   濃縮concentrated to dryness
4. 4
   その他Purification by CC(CH2Cl2/MeOH 97:3)

実験手順

To a solution of Example 61 (6 mg) in EtOH (0.2 mL) was added concentrated H2SO4 (20 μL), and the reaction mixture was stirred at RT for 1 h. The reaction mixture was diluted with H2O and extracted with EtOAc (2×). The combined org. layers were dried over Na2SO4 and concentrated to dryness. Purification by CC(CH2Cl2/MeOH 97:3) gave 3 mg of the desired product.

出典