反応 #1269863

反応方程式

4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester

HCl

→

4-(2-Amino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester hydrochloride

溶媒

Et2O

CH2Cl2

反応条件

後処理

1. 1
   ろ過the white cake was filtered
2. 2
   洗浄washed with Et2O
3. 3
   その他dried at HV overnight
4. 4
   その他The crude (1.19 g) was used without purification

実験手順

To a solution of 4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester (1.79 g, as described in WO2008044217) in CH2Cl2 (22 mL) was added HCl (4M in dioxane, 8.3 mL) and the reaction mixture was stirred for 2 h at RT. The suspension was diluted with Et2O (1000 mL) and the white cake was filtered, washed with Et2O and dried at HV overnight. The crude (1.19 g) was used without purification.

出典