反応 #1269855

ord-fe8bae641c0844f3abfd2eda1fa19f69

反応方程式

CC(C)(C)OC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)O
Boc-Phe(4-I)-OH
CCCCOC(=O)N1CCNCC1
piperazine-1-carboxylic acid butyl ester
→
CCCCOC(=O)N1CCN(C(=O)[C@H](Cc2ccc(I)cc2)NC(=O)OC(C)(C)C)CC1
4-[(S)-2-tert-Butoxycarbonylamino-3-(4-iodo-phenyl)-propionyl]-piperazine-1-carboxylic acid butyl ester

反応物

CC(C)(C)OC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)O
Boc-Phe(4-I)-OH
CCCCOC(=O)N1CCNCC1
piperazine-1-carboxylic acid butyl ester

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他This compound was prepared

実験手順

This compound was prepared using a method analogous to that of Example 8, step 8.5 Boc-Phe(4-I)-OH replacing 2-phenoxyphenylboronic acid and piperazine-1-carboxylic acid butyl ester replacing intermediate 8.4.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08664203B2uspto-grants-2014_03