反応 #1269836

反応方程式

3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole

water

formamide

→

4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine

反応条件

後処理

1. 1
   温度The reaction mixture is cooled to 30° C.
2. 2
   その他The solid is collected
3. 3
   洗浄washed well with water
4. 4
   乾燥with methanol and dried in air

実験手順

3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole (29.5 g) is suspended in formamide (300 mL) and heated under nitrogen at 180° C. for 4 hours. The reaction mixture is cooled to 30° C. and water (300 mL) is added. The solid is collected, washed well with water, then with methanol and dried in air to give of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine.

出典