反応 #1269820

反応方程式

methacryloyloxyacetic acid

dimethylformamide

thionyl chloride

→

methacryloyloxyacetyl chloride

反応条件

後処理

1. 1
   その他Into a 100-mL reaction vessel with a condenser
2. 2
   その他prepared in a method
3. 3
   workup.DISTILLATIONsubjected to distillation purification

実験手順

Into a 100-mL reaction vessel with a condenser were added 30 g (purity: 46%, 95.1 mmol) of methacryloyloxyacetic acid (prepared in a method described in International Publication No. 96/41841 and the like), 347 mg (4.8 mmol/0.05 eq) of dimethylformamide and 47.6 g (380.5 mmol/4.0 eq) of thionyl chloride. The resulting solution was stirred at 70° C. for 1 hour and subjected to distillation purification, thereby obtaining 10.0 g of target methacryloyloxyacetyl chloride. The purity of the target product was 70%; and the yield of the target product was 45%.

出典