反応 #1266

ord-7d431b55cb724be5bee26d49a4283c0c

反応方程式

CCOC(=O)c1cc2cc(N3CCN(C(=O)OC(C)(C)C)CC3)ccc2o1
ethyl 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxylate
NC=O
formamide
→
CC(C)(C)OC(=O)N1CCN(c2ccc3oc(C(N)=O)cc3c2)CC1
5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxamide

反応物

—
sodium alkoxide
CCOC(=O)c1cc2cc(N3CCN(C(=O)OC(C)(C)C)CC3)ccc2o1
ethyl 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxylate
NC=O
formamide

試薬

なし

溶媒

CN1CCCC1=O
N-methylpyrrolidone

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

A solution of 3 g of ethyl 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxylate in 100 ml of N-methylpyrrolidone is stirred for 5 hours with 1 g of formamide and 3 g of sodium alkoxide. After customary working up, 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxamide, m.p. 198°-200°, is obtained.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05723614uspto-grants-1998_03