反応 #1265389

反応方程式

5-Chloro-2-(1,1-dimethoxy-ethyl)-thiazole

trifluoroacetic acid

water

→

sub-titled compound

1-(5-Chloro-thiazol-2-yl)-ethanone

溶媒

dichloromethane

反応条件

後処理

1. 1
   濃縮concentrated to an oil
2. 2
   workup.ADDITIONdiluted with diethyl ether
3. 3
   洗浄washed with 10% sodium bicarbonate, water and brine
4. 4
   乾燥dried (magnesium sulfate)
5. 5
   ろ過filtered
6. 6
   濃縮concentrated

実験手順

To a solution of 5-Chloro-2-(1,1-dimethoxy-ethyl)-thiazole (3.5 g) in dichloromethane (20 ml) was added trifluoroacetic acid (30 ml) and water (1 ml). The resulting mixture was stirred overnight at ambient, concentrated to an oil, diluted with diethyl ether, washed with 10% sodium bicarbonate, water and brine, dried (magnesium sulfate), filtered and concentrated to afford the sub-titled compound as a yellow solid in quantitative yield (2.6 g); 1H NMR (400 Mhz, CDCl3) δ 2.7 (3H, s), 7.8 (1H, s).

出典