反応 #1265386

反応方程式

3-Nitro-5-trifluoromethyl-phenol

→

3-Amino-5-trifluoromethyl-phenol

収率 87.5%

溶媒

EtOAc

—

Hexanes

反応条件

後処理

1. 1
   ろ過The reaction was filtered

実験手順

To a solution of 3-Nitro-5-trifluoromethyl-phenol 44 (1.6 g, 7.73 mmol) was added a catalytic amount of 20% palladium hydroxide on carbon and the reaction was stirred under a hydrogen atmosphere (balloon) over the weekend resulting in complete conversion to product by TLC (40% EtOAc:Hexanes). The reaction was filtered to give 3-Amino-5-trifluoromethyl-phenol (1.2 g, 6.76 mmol) as a brown/red oil.

出典