反応 #1265385

反応方程式

EtOAc

1-Methoxy-3-nitro-5-trifluoromethyl-benzene

boron tribromide

→

3-Nitro-5-trifluoromethyl-phenol

収率 42.7%

溶媒

—

Hexanes

CHCl3

反応条件

後処理

1. 1
   その他The reaction was partitioned between CH2Cl2/1N NaOH
2. 2
   抽出extracted
3. 3
   抽出again extracted with CH2Cl2
4. 4
   乾燥The organics were dried over sodium sulfate

実験手順

To a solution of 1-Methoxy-3-nitro-5-trifluoromethyl-benzene (3.5 g, 15.83 mmol) in 20 ml of CHCl3 was added a solution of 1M boron tribromide (23.74 ml, 23.74 mmol) and the reaction was stirred at RT for 3 days resulting in conversion to product by TLC (20% EtOAc:Hexanes). The reaction was partitioned between CH2Cl2/1N NaOH and extracted. The aqueous phase was acidified with 1N HCl and again extracted with CH2Cl2. The organics were dried over sodium sulfate and stripped down in vacuo giving 3-Nitro-5-trifluoromethyl-phenol (1.4 g, 6.76 mmol) as a yellow oil.

出典