反応 #1265381

反応方程式

2a

1-(4-Methyl-thiazol-2-yl)-ethanone

NBS

→

desired product 3a

収率 72.6%

1-(4-Bromomethyl-thiazol-2-yl)-ethanone

収率 72.6%

溶媒

carbon tetrachloride

反応条件

後処理

1. 1
   ろ過the precipitate was filtered
2. 2
   濃縮The solvent was concentrated in vacuo to an oil that

実験手順

A solution of 2a (4.38 g, 0.031 mol), NBS (5.8 g, 0.033 mol) and 100 mg of AIBN in 40 mL of carbon tetrachloride was heated at 70° C. for 16 h. Cooled to rt and the precipitate was filtered. The solvent was concentrated in vacuo to an oil that was subjected to flash chromatography (5% ethyl acetate/95% hexanes) to give 4.95 g (72%) of the desired product 3a. 1H NMR (CDCl3) δ 7.8 (s, 1H), 4.8 (s, 2H), 2.8 (s, 3H).

出典