反応 #1265

反応方程式

ethyl 5-nitrobenzofuran-2-carboxylate

→

ethyl 5-aminobenzofuran-2-carboxylate

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The catalyst is filtered off
2. 2
   濃縮the solution is concentrated

実験手順

A solution of 2.3 g of ethyl 5-nitrobenzofuran-2-carboxylate in 60 ml of methanol is hydrogenated in the presence of Raney nickel. The catalyst is filtered off and the solution is concentrated. After customary working up, ethyl 5-aminobenzofuran-2-carboxylate, Rf 0.1 (dichloromethane/ethanol 9.5:0.5) obtained; hydrochloride m.p. 246°-248°.

出典