反応 #1261559

ord-b2894561c7914198ba750d8652d40cbb

反応方程式

CC(C)(C)OC(=O)[C@@H](NS(C)(=O)=O)C(C)(C)C
solution
CC(C)(C)OC(=O)[C@@H](NS(C)(=O)=O)C(C)(C)C
tert-butyl 3-methyl-N-(methylsulfonyl)-L-valinate
→
CC(C)(C)[C@H](NS(C)(=O)=O)C(=O)O
crude title compound
収率 106.4%
CC(C)(C)[C@H](NS(C)(=O)=O)C(=O)O
3-methyl-N-(methylsulfonyl)-L-valine
収率 106.4%

反応物

CC(C)(C)OC(=O)[C@@H](NS(C)(=O)=O)C(C)(C)C
solution
CC(C)(C)OC(=O)[C@@H](NS(C)(=O)=O)C(C)(C)C
tert-butyl 3-methyl-N-(methylsulfonyl)-L-valinate

試薬

なし

溶媒

Cl
HCl
C1COCCO1
dioxane

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他the solvents were evaporated

実験手順

A solution of Example 152A (59 mg, 0.22 mmol) in 4N HCl in dioxane (1 mL) at 25° C. for 4 h, and the solvents were evaporated to give the crude title compound (49 mg, 100%).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07834043B2uspto-grants-2010_11