反応 #1256751

反応方程式

ammonium chloride

Magnesium

iodine

diisopropylchlorosilane

1-Bromo-3-ethoxypropane

→

liquid

収率 107.4%

(3-Ethoxypropyl)diisopropylsilane

収率 107.4%

溶媒

THF

THF

反応条件

後処理

1. 1
   抽出the resultant mixture was extracted with pentane
2. 2
   洗浄by washing with water six times
3. 3
   乾燥drying over sodium sulfate anhydrate
4. 4
   その他The solvent was removed under reduced pressure, whereby the Compound 61a

実験手順

1-Bromo-3-ethoxypropane (5.85 g, 35.0 mmol) was dissolved in THF (30 mL). Magnesium (900 mg, 37.0 mmol) and iodine (catalytic amount) were added thereto, and the resultant mixture was stirred at room temperature for 30 minutes and at 60° C. for 10 minutes. The resultant mixture was added dropwise to diisopropylchlorosilane (5.12 mL, 30.0 mmol) in THF (40 mL), followed by stirring at room temperature for 15 minutes and at 60° C. for 1.5 hours. Saturated aqueous ammonium chloride was added thereto, and the resultant mixture was extracted with pentane, followed by washing with water six times and drying over sodium sulfate anhydrate. The solvent was removed under reduced pressure, whereby the Compound 61a was obtained as an yellow liquid (6.52 g, 92%).

出典