反応 #1256746

反応方程式

ammonium chloride

n-pentane

Diisopropylchlorosilane

→

n-Butyldiisopropylsilane

溶媒

THF

反応条件

後処理

1. 1
   workup.WAITThe reaction mixture was left
2. 2
   温度to cool
3. 3
   洗浄The formed organic layer was washed three times with water
4. 4
   乾燥once with saturated brine, and the thus-washed layer was dried over sodium sulfate anhydrate
5. 5
   その他The solvent was removed
6. 6
   workup.DISTILLATIONfollowed by purification through distillation under reduced pressure, whereby the Compound 47a
7. 7
   その他was obtained as a colorless liquid (boiling point; 50 mmHg, 93.2 to 95.5° C. fraction, 8.43 g, 64%)

実験手順

Diisopropylchlorosilane (13.1 mL, 76.8 mmol) was dissolved in THF (75 mL), and n-butylmagnesium chloride THF solution (0.84M, 100 mL, 84 mmol) was added dropwise thereto in a nitrogen atmosphere for 10 minutes. Subsequently, cuprous bromide (286 mg, 2.00 mmol) was added to the resultant mixture, followed by stirring at 65° C. for 8 hours. The reaction mixture was left to cool, and saturated aqueous ammonium chloride and n-pentane were added thereto. The formed organic layer was washed three times with water and once with saturated brine, and the thus-washed layer was dried over sodium sulfate anhydrate. The solvent was removed, followed by purification through distillation under reduced pressure, whereby the Compound 47a was obtained as a colorless liquid (boiling point; 50 mmHg, 93.2 to 95.5° C. fraction, 8.43 g, 64%).

出典