反応 #1256

反応方程式

sodium borohydride

2-(4-acetylphenyl)-5-decyloxypyrimidine

ethanol

chloroform

→

2-(4-(1-hydroxyethyl) phenyl)-5-decyloxypyrimidine

収率 100.3%

溶媒

water

反応条件

後処理

1. 1
   その他equipped with a stirrer
2. 2
   その他The resulting reaction mixture
3. 3
   抽出followed by extraction and liquid separation
4. 4
   洗浄the obtained chloroform layer was washed with water
5. 5
   乾燥dried over anhydrous magnesium sulfate
6. 6
   濃縮concentrated under reduced pressure

実験手順

35.5 g (0.1 mo1) of 2-(4-acetylphenyl)-5-decyloxypyrimidine, 300 ml of ethanol and 300 ml of chloroform were supplied into a four-necked flask equipped with a stirrer and a thermometer. Then 2.8 g (0.075 mol) of sodium borohydride was added at 30°-40° C. and the mixture was stirred at the same temperature for 4 hours. The resulting reaction mixture was poured into 500 ml of water, followed by extraction and liquid separation, and the obtained chloroform layer was washed with water, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 35.8 g of 2-(4-(1-hydroxyethyl) phenyl)-5-decyloxypyrimidine (II-c-11) (yield: 100%).

出典