反応 #1255770

ord-a5eb0643ac4e4b3885a28d3e6c45f048

反応方程式

COCCO[C@@H]1[C@H](O)[C@@H](CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)O[C@H]1n1cc(C)c(=O)[nH]c1=O
5′-O-t-Butyldiphenylsilyl-2′-O-(methoxyethyl)-5-methyluridine
CCCC[N+](CCCC)(CCCC)CCCC.[F-]
TBAF
→
COCCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cc(C)c(=O)[nH]c1=O
title compound
COCCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cc(C)c(=O)[nH]c1=O
2′-O-(Methoxyethyl)-5-methyluridine

反応物

COCCO[C@@H]1[C@H](O)[C@@H](CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)O[C@H]1n1cc(C)c(=O)[nH]c1=O
5′-O-t-Butyldiphenylsilyl-2′-O-(methoxyethyl)-5-methyluridine
CCCC[N+](CCCC)(CCCC)CCCC.[F-]
TBAF

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

5′-O-t-Butyldiphenylsilyl-2′-O-(methoxyethyl)-5-methyluridine is treated with TBAF as per the procedure of Example 8 above to give the title compound.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06624294B2uspto-grants-2003_09