反応 #1253969

反応方程式

1-methylnaphthalene

HNO3

H2SO4

→

4-Nitro-1-methylnaphthalene

溶媒

ethyl acetate

反応条件

後処理

1. 1
   その他the reaction for one hour
2. 2
   洗浄washed with water (3×), aqueous saturated NaHCO3 (2×) and brine
3. 3
   乾燥dried over MgSO4
4. 4
   濃縮concentrated
5. 5
   その他The product was purified by silica gel column chromatography
6. 6
   その他recrystallized from methanol
7. 7
   その他to give yellow needles

実験手順

To a cold (0° C.) suspension of 1-methylnaphthalene (5 g) in HNO3 was added H2SO4 (5 mL) dropwise. After stirring the reaction for one hour, the solution was diluted with ethyl acetate and washed with water (3×), aqueous saturated NaHCO3 (2×) and brine, dried over MgSO4, and concentrated. The product was purified by silica gel column chromatography using ethyl acetate:hexane (5:95) and recrystallized from methanol to give yellow needles.

出典