反応 #1253193
ord-648c7f6b770c4fe780d8129ffd23db80
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1洗浄The reaction mixture was then washed with 20% sodium chloride solution (500 ml)
- 2乾燥The washed organic layer was dried over anhydrous sodium sulphate
- 3その他Removal of solvent under vacuo
- 4その他resulted in colorless oil that
実験手順
To a stirred and a cooled solution of lauryl alcohol (186.0 g, 1.0 mole) and triethyl amine (121.0 g, 1.2 mole) in dichloromethane (600 ml), p-toluene sulphonyl chloride (228.0 g, 1.2 mole) in dichloromethane (400 ml) was slowly added and the reaction was continued at room temperature for 10 hours. The reaction mixture was then washed with 20% sodium chloride solution (500 ml). The washed organic layer was dried over anhydrous sodium sulphate. Removal of solvent under vacuo resulted in colorless oil that solidified on keeping to yield lauryl tosylate. (309.0 g, 91%), m. p. 29° C. (literature m. p. 29° C.).