反応 #1251701

反応方程式

sodium ethoxide

sodium

hydrochloric acid

2-bromo-4-phenoxybenzothiazole

→

2-oxo-4-phenoxybenzothiazoline

溶媒

ethanol

acetone

反応条件

後処理

1. 1
   温度The mixture was refluxed
2. 2
   その他The solvent was removed under reduced pressure
3. 3
   その他to give a residue
4. 4
   workup.STIRRINGwith stirring for 2 hours
5. 5
   その他The solvent was removed under reduced pressure
6. 6
   その他to give a residue, which
7. 7
   その他was recrystallized from a mixture of ethanol and n-hexane

実験手順

To a sodium ethoxide solution prepared with sodium metal (460 mg) and anhydrous ethanol (50 ml) was added 2-bromo-4-phenoxybenzothiazole (3.0 g). The mixture was refluxed with stirring 45 minutes. The solvent was removed under reduced pressure to give a residue, to which was added 10% hydrochloric acid (30 ml) and acetone (50 ml). The resultant mixture was refluxed with stirring for 2 hours. The solvent was removed under reduced pressure to give a residue, which was recrystallized from a mixture of ethanol and n-hexane to give crystalline 2-oxo-4-phenoxybenzothiazoline (2.0 g).

出典