反応 #1245

反応方程式

( 17 )

2-amino-4'-fluorobenzophenone

4-fluoroacetophenone

toluene sulfonic acid monohydrate

→

2,4-bis(4-fluorophenyl)quinoline

溶媒

water

反応条件

後処理

1. 1
   その他removed
2. 2
   温度the mixture is cooled
3. 3
   その他the crude solid product is crushed
4. 4
   洗浄washed with hot ethanol The product
5. 5
   その他is further recrystallized from toluene

実験手順

A flask is loaded with (17) (21.5 g, 0.1 mol), 4-fluoroacetophenone (13.8 g, 0.1 mol), and toluene sulfonic acid monohydrate (3.8 g, 0.02 mol). The flask is heated to 200° C. and the water of condensation removed. After water evolution ceased, the mixture is cooled and the crude solid product is crushed and washed with hot ethanol The product is further recrystallized from toluene.

出典