反応 #1244252

反応方程式

triethyl amine

Tetraethylene glycol

TBDMSCl

→

5c

収率 42.0%

2-(2-{2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethanol

収率 42.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他After standard workup with dichloromethane, the residue was purified by silica gel column chromatography (50% ethyl acetate in hexane)

実験手順

Tetraethylene glycol, 4c (1.12 g, 5.77 mmol) and TBDMSCl (0.87 g, 5.77 mmol) were dissolved in dichloromethane (25 ml) followed by triethyl amine (1.46 g, 14.4 mmol). The solution was stirred at room temperature for 2 hours. After standard workup with dichloromethane, the residue was purified by silica gel column chromatography (50% ethyl acetate in hexane) to afford 5c (744 mg, 42%): 1H NMR δ 3.66 (m, 16H), 2.51 (t, 1H, J=5.86 Hz), 0.89 (s, 9H), 0.07 (s, 6H).

出典