反応 #1227

反応方程式

water

sodium hydride

methyl 2-hydroxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthryl)benzoate

iodomethane

→

methyl 2-methoxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthryl)benzoate

溶媒

DMF

DMF

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for two hours
2. 2
   抽出extracted with ethyl ether
3. 3
   その他the organic phase decanted
4. 4
   乾燥dried over magnesium sulfate
5. 5
   その他evaporated
6. 6
   その他1.6 g (96%) of the expected compound was recovered in the form of a colorless oil

実験手順

130 mg (4.2 mmol) of sodium hydride (80% in oil) and 20 ml of DMF were introduced into a three-necked flask, a solution of 1.6 g (4.2 mmol) of methyl 2-hydroxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthryl)benzoate in 50 ml of DMF was added dropwise and the mixture was stirred until gaseous emission ceased. 340 μl (5.5 mmol) of iodomethane were then added and the mixture was stirred at room temperature for two hours. The reaction medium was poured into water, extracted with ethyl ether, the organic phase decanted, dried over magnesium sulfate and evaporated. 1.6 g (96%) of the expected compound was recovered in the form of a colorless oil.

出典