反応 #1224

反応方程式

4-iodo-2-trichloroacetylpyrrole

methanol

sodium methoxide

→

methyl 4-iodo-2-pyrrolecarboxylate

溶媒

water

ethyl ether

反応条件

後処理

1. 1
   その他the reaction medium evaporated to dryness
2. 2
   その他the residue obtained
3. 3
   その他The organic phase was decanted off
4. 4
   乾燥dried over magnesium sulfate
5. 5
   その他evaporated
6. 6
   その他The residue obtained
7. 7
   その他was triturated in heptane
8. 8
   ろ過filtered
9. 9
   その他4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered

実験手順

8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. The mixture was stirred at room temperature for four hours, the reaction medium evaporated to dryness, and the residue obtained taken up in water and ethyl ether. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered; 4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered.

出典