反応 #1222

反応方程式

ester

ethyl 2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthryl)-4-thiophenecarboxylate

sodium hydroxide

→

2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthryl)-4-thiophenecarboxylic acid

反応条件

後処理

1. 1
   温度the mixture was heated
2. 2
   温度at reflux for one hour
3. 3
   その他The reaction medium was evaporated to dryness
4. 4
   ろ過the solids filtered
5. 5
   その他The product obtained
6. 6
   その他was recrystallized from an ethyl alcohol/water mixture and 4.5 g (77%) of the expected acid of melting point 223°-225° C.
7. 7
   その他were recovered

実験手順

6.3 g (16 mmol) of the ester prepared in Example 1 and 100 ml of a 2N methanolic sodium hydroxide solution were introduced into a round-bottomed flask and the mixture was heated at reflux for one hour. The reaction medium was evaporated to dryness, the residue taken up in water, acidified to pH 1 with concentrated hydrochloric acid and the solids filtered. The product obtained was recrystallized from an ethyl alcohol/water mixture and 4.5 g (77%) of the expected acid of melting point 223°-225° C. were recovered.

出典