反応 #1217

反応方程式

benzylamine

1,2-epoxy-3-tridecanol

→

title compound

収率 72.0%

1-benzylaminotridecane-2,3-diol

収率 72.0%

溶媒

dioxane

反応条件

後処理

1. 1
   その他A 500-ml flask equipped with a stirrer
2. 2
   workup.ADDITIONwas added dropwise over 2 hours
3. 3
   workup.DISTILLATIONDioxane and excess benzylamine were distilled off under reduced pressure
4. 4
   その他The resultant residue was recrystallized from hexane

実験手順

A 500-ml flask equipped with a stirrer was charged with 107 g (1 mol) of benzylamine, to which a solution of 5.2 g (71 mmol) of 1,2-epoxy-3-tridecanol in 170 ml of dioxane was added dropwise over 2 hours. After completion of the dropping, a reaction was conducted further for 12 hours at 80° C. Dioxane and excess benzylamine were distilled off under reduced pressure. The resultant residue was recrystallized from hexane, thereby obtaining 16.4 g (yield: 72%) of the title compound (IIh-1).

出典