反応 #1209

反応方程式

1,2-epoxy-16-hexadecanol

ethanolamine

N2

ethanolamine

→

title compound

収率 68.0%

1-(2-hydroxyethylamino)-2,16-hexadecanediol

収率 68.0%

溶媒

ethanol

ethanol

ethanol

反応条件

後処理

1. 1
   その他A 50-ml two-necked flask equipped with a stirrer
2. 2
   温度While heating
3. 3
   workup.DISTILLATIONwere distilled off under reduced pressure
4. 4
   その他the resultant residue was purified by flash column chromatography on silica gel

実験手順

A 50-ml two-necked flask equipped with a stirrer, dropping funnel and N2 inlet tube was charged with 4.14 g (68 mmol) of ethanolamine and 0.8 g of ethanol. While heating and stirring the mixture at 80° C. in an N2 atmosphere, an ethanol solution of 0.87 g (3.4 mmol) of 1,2-epoxy-16-hexadecanol was added dropwise over 1.5 hours. The resultant mixture was stirred further for 2 hours at 80° C. After completion of the reaction, ethanol and excess ethanolamine were distilled off under reduced pressure, and the resultant residue was purified by flash column chromatography on silica gel, thereby obtaining 0.72 g (yield: 68%) of the title compound (IId-1).

出典