反応 #1205

反応方程式

1,2-epoxyoctadecane

N-methylethanolamine

→

title compound

収率 67.0%

1-[N-(2-hydroxyethyl)-N-methylamino)-2-octadecanol

収率 67.0%

溶媒

ethanol

反応条件

後処理

1. 1
   その他A 300-ml flask equipped with a stirrer
2. 2
   workup.DISTILLATIONAfter the solvent was distilled off under reduced pressure
3. 3
   その他the resultant residue was purified by column chromatography on silica gel

実験手順

A 300-ml flask equipped with a stirrer was charged with 26.85 g (0.1 mol) of 1,2-epoxyoctadecane, 7.51 g (0.1 mol) of N-methylethanolamine and 50 ml of ethanol, and the contents were stirred at 80° C. for 18 hours. After the solvent was distilled off under reduced pressure, the resultant residue was purified by column chromatography on silica gel, thereby obtaining 23.0 g (yield: 67%) of the title compound (IIc-2).

出典