反応 #12022

ord-ec280414291745f18f96f4f9f83936e4

反応方程式

C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(CO)nc3N21
(4R,9aR)-6-hydroxymethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester
[H-].[Na+]
sodium hydride
COCCBr
2-bromoethyl methyl ether
→
COCCOCc1ccc2c(n1)N1[C@H](C2)CN(C(=O)OC(C)(C)C)C[C@H]1C
(4R,9aR)-6-(2-Methoxy-ethoxymethyl)-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

反応物

—
intermediate c
C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(CO)nc3N21
(4R,9aR)-6-hydroxymethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester
[H-].[Na+]
sodium hydride
COCCBr
2-bromoethyl methyl ether

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

This compound was prepared in analogy to Example 15 intermediate c), from (4R,9aR)-6-hydroxymethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester, sodium hydride and 2-bromoethyl methyl ether.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07098337B2uspto-grants-2006_08