反応 #12010

ord-9e857f4086cd4f5592763c9b4669cb23

反応方程式

C[C@@H]1CNC(=O)c2cc3ccc(Cl)nc3n21
intermediate b
C[C@@H]1CNC(=O)c2cc3ccc(Cl)nc3n21
(R)-6-chloro-4-methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one
C[C@@H]1CN(C(=O)OC(C)(C)C)Cc2cc3ccc(Br)nc3n21
(R)-6-bromo-4-methyl-3,4-dihydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester
[BH3-]C#N.[Na+]
sodium cyano borohydride
→
C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@@H]2Cc3ccc(Br)nc3N21
(4R,9aS)-6-Bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

反応物

C[C@@H]1CNC(=O)c2cc3ccc(Cl)nc3n21
intermediate b
C[C@@H]1CNC(=O)c2cc3ccc(Cl)nc3n21
(R)-6-chloro-4-methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one
C[C@@H]1CN(C(=O)OC(C)(C)C)Cc2cc3ccc(Br)nc3n21
(R)-6-bromo-4-methyl-3,4-dihydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester
[BH3-]C#N.[Na+]
sodium cyano borohydride

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

This compound was prepared in analogy to Example 2, intermediate b) from (R)-6-bromo-4-methyl-3,4-dihydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester and sodium cyano borohydride.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07098337B2uspto-grants-2006_08