反応 #1201

反応方程式

tetradecyl glycidyl ether

ethanol

glycine

NaOH

ethanol

hydrochloride

→

title compound

収率 30.7%

4-(2-hydroxyethylamino)-1-dodecyloxy-2-methyl-2-butanol

収率 30.7%

反応条件

後処理

1. 1
   その他A 300-ml two-necked flask equipped with a stirrer
2. 2
   workup.DISTILLATIONAfter ethanol was distilled off under reduced pressure, methanol and hydrochloric acid
3. 3
   workup.ADDITIONwas added to the mixture
4. 4
   抽出The mixture was subjected to extraction with chloroform
5. 5
   抽出The resultant extract
6. 6
   濃縮was concentrated under reduced pressure
7. 7
   その他the residue was then purified by column chromatography on silica gel

実験手順

A 300-ml two-necked flask equipped with a stirrer was charged with 7.51 g (0.1 mol) of glycine, 8.3 g (0.1 mol) of 48% NaOH and 200 ml of ethanol. While stirring the mixture at 80° C., an ethanol solution of 2.70 g (10 mmol) of tetradecyl glycidyl ether was added, and the resultant mixture was stirred for 3 hours. After ethanol was distilled off under reduced pressure, methanol and hydrochloric acid was added to the mixture to acidify it. The mixture was subjected to extraction with chloroform. The resultant extract was concentrated under reduced pressure, and the residue was then purified by column chromatography on silica gel, thereby obtaining 1.17 g (yield: 30.7%) of the title compound [(IIa-10) hydrochloride].

出典