反応 #1199

反応方程式

ethanolamine

1,2-epoxy-2-methyl-3-tetradecyloxypropane

→

title compound

収率 68.0%

1-(2-hydroxyethylamino)-2-methyl-3-tetradecyloxy-2-propanol

収率 68.0%

溶媒

ethanol

ethanol

反応条件

後処理

1. 1
   その他A 100-ml flask equipped with a stirrer
2. 2
   workup.STIRRINGThe contents were stirred further for 2 hours
3. 3
   その他The resultant reaction mixture
4. 4
   濃縮was concentrated under reduced pressure
5. 5
   その他the resultant residue was purified by column chromatography on silica gel

実験手順

A 100-ml flask equipped with a stirrer and dropping funnel was then charged with 16.8 g (280 mmol) of ethanolamine and 15 g of ethanol. While stirring the mixture at 80° C., an ethanol solution of 5.00 g (17.6 mmol) of 1,2-epoxy-2-methyl-3-tetradecyloxypropane was added dropwise over 3 hours. The contents were stirred further for 2 hours. The resultant reaction mixture was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 4.13 g (yield: 68%) of the title compound.

出典