反応 #11971

反応方程式

compound

(2S)-2-(4-(N-Boc-N-2-picolylamino)methylnaphthalene-1-carbonyl)amino-5-((8S)-5,6,7,8-tetrahydroquinolin-8-yl)aminovaleric acid 1-naphthylmethylamide

hydrochloric acid dioxane

→

hydrochloride

title compound

(2S)-2-(4-(N-2-picolylaminomethyl)naphthalene-1-carbonyl)amino-5-((8S)-5,6,7,8-tetrahydroquinolin-8-yl)aminovaleric acid 1-naphthylmethylamide

溶媒

methanol

反応条件

後処理

1. 1
   その他After the reaction for 3.5 hours
2. 2
   濃縮the reaction solution was concentrated
3. 3
   その他The residue obtained
4. 4
   その他was purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5)
5. 5
   workup.ADDITIONtreated with hydrochloric acid

実験手順

The compound obtained in Example 90-2 (14.2 mg) was dissolved in methanol (0.3 ml), and 4 mol/l hydrochloric acid/dioxane solution (0.3 ml) was added to the solution. After the reaction for 3.5 hours, the reaction solution was concentrated. The residue obtained was purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5) and treated with hydrochloric acid to obtain hydrochloride of the title compound (8.1 mg) as a white solid.

出典