反応 #1197

反応方程式

11-(butyldimethylsilyl)undecyl glycidyl ether

ethanolamine

N2

ethanolamine

→

title compound

収率 73.3%

1-(2-hydroxyethylamino)-3-[11-(butyldimethylsilyl)undecyloxy]-2-propanol

収率 73.3%

溶媒

ethanol

ethanol

ethanol

反応条件

後処理

1. 1
   その他A 100-ml two-necked flask equipped with a stirrer
2. 2
   workup.DISTILLATIONwere distilled off under reduced pressure
3. 3
   その他the resultant residue was purified by column chromatography on silica gel

実験手順

A 100-ml two-necked flask equipped with a stirrer, dropping funnel and N2 inlet tube was charged with 4.58 g (75 mmol) of ethanolamine and 9.2 g of ethanol. The contents were heated to 80° C. with stirring in an N2 atmosphere, and an ethanol solution of 1.71 g (5 mmol) of 11-(butyldimethylsilyl)undecyl glycidyl ether was added dropwise to the contents over 1 hour. The resultant mixture was stirred further for 1 hour at 80° C. After completion of the reaction, ethanol and excess ethanolamine were distilled off under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 1.48 g (yield: 73%) of the title compound (Ia-18).

出典