反応 #11950

反応方程式

8-Aminoquinoline

potassium carbonate

methyl 4-bromomethylbenzoate

→

title compound

収率 172.4%

Methyl 4-(8-quinolylaminomethyl)benzoate

収率 172.4%

溶媒

DMF

反応条件

後処理

1. 1
   濃縮the reaction solution was concentrated
2. 2
   workup.ADDITIONThe resulting residue was diluted with chloroform and water
3. 3
   workup.ADDITIONwas added
4. 4
   抽出The mixture was extracted with chloroform
5. 5
   洗浄The organic layer was washed with saturated brine
6. 6
   乾燥dried over anhydrous sodium sulfate
7. 7
   濃縮concentrated

実験手順

8-Aminoquinoline (1.26 g) was dissolved in DMF (20 ml), and potassium carbonate (1.2 g) and methyl 4-bromomethylbenzoate (1.0 g) were added. After stirring for 20 hours, the reaction solution was concentrated. The resulting residue was diluted with chloroform and water was added. The mixture was extracted with chloroform. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated to obtain the title compound (2.20 g) as a yellow syrup.

出典