反応 #1195

反応方程式

ethanolamine

ethanol

ethanol

butyl 12-(2,3-epoxypropoxy)-dodecanate

→

title compound

収率 55.4%

butyl 12-[2-hydroxy-3-(2-hydroxyethylamino)propoxy]dodecanate

収率 55.4%

溶媒

water

反応条件

後処理

1. 1
   その他A 100-ml flask equipped with a stirrer
2. 2
   workup.ADDITIONwas added to the reaction mixture
3. 3
   抽出followed by extraction with chloroform
4. 4
   濃縮The resultant chloroform solution was concentrated under reduced pressure
5. 5
   その他the resultant residue was purified by column chromatography on silica gel

実験手順

A 100-ml flask equipped with a stirrer and dropping funnel was charged with 23.7 g (250 mmol) of ethanolamine and 23.7 g of ethanol. While stirring the mixture at 80° C., an ethanol solution of 8.20 g (25 mmol) of butyl 12-(2,3-epoxypropoxy)-dodecanate was added dropwise over 1 hour. After completion of the reaction, water was added to the reaction mixture, followed by extraction with chloroform. The resultant chloroform solution was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 5.40 g (yield: 55.4%) of the title compound (Ia-15).

出典