反応 #1194

反応方程式

ethanolamine

10-(2-ethylhexyloxy)decyl glycidyl ether

→

title compound

収率 68.4%

1-(2-hydroxyethylamino)-3-[10-(2-ethylhexyloxy)decyloxy]-2-propanol

収率 68.4%

溶媒

ethanol

反応条件

後処理

1. 1
   その他A 200-ml two-necked flask equipped with a stirrer
2. 2
   温度reflux tube
3. 3
   温度While heating
4. 4
   workup.STIRRINGstirred further for 18 hours
5. 5
   濃縮it was concentrated under reduced pressure
6. 6
   その他the resultant residue was purified by column chromatography on silica gel

実験手順

A 200-ml two-necked flask equipped with a stirrer, reflux tube and dropping funnel was charged with 32.7 g (0.54 mol) of ethanolamine and 10.1 g of ethanol. While heating and stirring the mixture at 80° C., 1.76 g (5.14 mmol) of 10-(2-ethylhexyloxy)decyl glycidyl ether were added dropwise over 2 hours. After the resultant mixture was heated and stirred further for 18 hours, it was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 1.42 g (yield: 68%) of the title compound (Ia-14).

出典